Route 322 is closed eastbound near Lewistown for a crash in the westbound lanes.
The eastbound lanes will be closed until later this afternoon, according to a PennDOT news release.
The westbound lanes were closed for the emergency response but reopened around 9:45 a.m.
Drivers should follow the Blue Detour which directs them to follow Business Route 22 and Route 522.
The Blue Detours is marked with Blue Detour signs.