A 35-year-old Harrisburg man was fatally shot early Friday in the 1100 block of Hanover Street.
Ronald McGruder was found lying on a sidewalk when officers responded to a report of shots fired around 2 a.m., police said.
Investigators said McGruder had been shot multiple times in the head and was pronounced dead at the scene.
Authorities have no suspects, and the motive for the slaying is unknown.
According to police, a full-sized sedan was seen leaving northbound on Cameron Street from Hanover Street, and may have had a near collision with a driver heading north on Cameron.
Police are looking for information regarding the vehicle and the homicide. Anyone with information may call 717-255-3118 or 717-255-3170.